منابع مشابه
Systemic therapy for locally advanced and metastatic cholangiocarcinoma.
Cholangiocarcinoma, the typical bile duct epithelium neoplasm, is most commonly reported in the Northeast of Thailand. Surgical intervention is the only possible curative treatment in the early stage of disease. Unfortunately, most patients are advanced at the time of diagnosis and not appropriate for curative surgical treatment. The prognosis of advanced CCA is extremely poor and chemotherapy ...
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Hepatic resection and transplantation are the only potentially curative options for cholangiocarcinoma.1,2 Unfortunately, only approximately 30% of patients are considered surgical candidates at the time of diagnosis and the overall 5-year survival rates range from 33 to 65%.3 Given the dismal outcomes of systemic chemotherapy, other therapeutic options may have a potential role for patients wi...
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Haroon Shahid, MD, Fellow, Division of Gastroenterology and Hepatology David Loren, MD FASGE, Associate Director, Gastrointestinal Endoscopy, Associate Professor of Medicine Sidney Kimmel College of Medicine Thomas Jefferson University Cholangiocarcinoma of the biliary hilum is an uncommon disease but increasing in incidence. Patients affected by this frequently fatal disease often succumb to c...
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Hilar cholangiocarcinoma (HCCA) is characterised by late clinical symptoms. As a consequence, most patients will not undergo surgery, and palliation is the main goal of therapy. For the few patients that undergo potentially curative surgery, the need for preoperative biliary drainage (PBD) continues to be debated and remains controversial, as there are many reports with conflicting results. For...
متن کاملEmerging molecular targets and therapy for cholangiocarcinoma
Cholangiocarcinoma (CCA) is a rare cancer arising from the biliary tree with a poor prognosis and limited therapeutic options. Recent large scale molecular characterisation studies have identified recurrent genetic alterations in CCA which may be amenable to therapeutic targeting. In this review we explore the genomic landscape of CCA and examine results from trials of molecularly targeted agen...
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ژورنال
عنوان ژورنال: Clinical Liver Disease
سال: 2014
ISSN: 2046-2484,2046-2484
DOI: 10.1002/cld.337